Spravato® is the first FDA approved prescription nasal spray for treatment-resistant depression, providing relief in as little as 24 hours.
Used to treat adults with treatment-resistent depression or major depressive disorder with suicidal ideation, Spravato (esketamine) is administered as a nasal spray under healthcare supervision. Unlike oral antidepressants, Spravato is a novel mechanism that acts on different receptors (NMDA vs serotonin receptors) to treat depression and bring fast relief.

For adults struggling with treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal thoughts or actions.
About 70% of patients show a clinically meaningful response, with treatments easily integrated into your life.
Spravato is covered by several major insurance payers, making it an accessible option for many if you've tried antidepressants and therapy.

Induction: Twice a week for the first four weeks
Optimization: Once a week for the following four weeks
Maintenance: Weekly or Bi-weekly Treatments for up to 12 months
Must be taken with an oral antidepressant
Avoid eating 2 hours before, and drinking liquids 30 minutes before treatment
Following administration, you will be observed for 2 hours by your provider
Patient cannot drive from their appointment on treatment days due to side effects, find your ride!


Dr. Thomas Knightly is a psychiatrist practicing in Stamford, CT. He is board-certified in general psychiatry as well as fellowship-trained in advanced treatments including Transcranial Magnetic Stimulation (TMS) and electroconvulsive therapy (ECT). He specializes in providing cutting edge, highly-effective, and fast-acting treatments to those who suffer with mental health.
Additionally, he is an Assistant Clinical Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University, where he works as a member of the Stanford Brain Stimulation Lab. The lab is responsible for developing and implementing cutting edge psychiatric treatments, including the highly effective, accelerated TMS treatment SAINT. It is Dr. Knightly's passion to bring advanced treatments, usually only available from top-tier academic institutions, to the community at large.